Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability

Septic shock is characterized by dysregulated vascular permeability. We hypothesized that the vascular permeability of endothelial cells (ECs) would be regulated by serotonin via serotonin-Rho-associated kinase (ROCK) signaling. We aimed to determine the impact of 5-hydroxyindoleacetic acid (5-HIAA)...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tanaka, Takeshi, Mori, Masahiko, Sekino, Motohiro, Higashijima, Ushio, Takaki, Masahiro, Yamashita, Yoshiro, Kakiuchi, Satoshi, Tashiro, Masato, Morimoto, Konosuke, Tasaki, Osamu, Izumikawa, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266895/
https://ncbi.nlm.nih.gov/pubmed/34238999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93649-z
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