Impact of plasma 5-hydroxyindoleacetic acid, a serotonin metabolite, on clinical outcome in septic shock, and its effect on vascular permeability

Septic shock is characterized by dysregulated vascular permeability. We hypothesized that the vascular permeability of endothelial cells (ECs) would be regulated by serotonin via serotonin-Rho-associated kinase (ROCK) signaling. We aimed to determine the impact of 5-hydroxyindoleacetic acid (5-HIAA)...

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Udgivet i:Sci Rep
Main Authors: Tanaka, Takeshi, Mori, Masahiko, Sekino, Motohiro, Higashijima, Ushio, Takaki, Masahiro, Yamashita, Yoshiro, Kakiuchi, Satoshi, Tashiro, Masato, Morimoto, Konosuke, Tasaki, Osamu, Izumikawa, Koichi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266895/
https://ncbi.nlm.nih.gov/pubmed/34238999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-93649-z
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