Therapeutic intradermal delivery of tumor necrosis factor-alpha antibodies using tip-loaded dissolvable microneedle arrays

Tumor necrosis factor-alpha (TNF-α) specific antibodies (anti-TNF-α Ab) have been shown to be potent TNF inhibitors and effective therapeutics for a range of inflammatory diseases. Typically, these drugs are administered systemically, but systemic dosing sufficient to achieve locally effective conce...

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Vydáno v:Acta Biomater
Hlavní autoři: Korkmaz, Emrullah, Friedrich, Emily E., Ramadan, Mohamed H., Erdos, Geza, Mathers, Alicia R., Ozdoganlar, O. Burak, Washburn, Newell R., Falo, Louis D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8266287/
https://ncbi.nlm.nih.gov/pubmed/26093066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2015.05.036
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