MTR3D: identifying regions within protein tertiary structures under purifying selection

The identification of disease-causal variants is non-trivial. By mapping population variation from over 448,000 exome and genome sequences to over 81,000 experimental structures and homology models of the human proteome, we have calculated both regional intolerance to missense variation (Missense To...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: Silk, Michael, Pires, Douglas E V, Rodrigues, Carlos H M, D’Souza, Elston N, Olshansky, Moshe, Thorne, Natalie, Ascher, David B
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2021
Teme:
Web Server Issue
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265191/
https://ncbi.nlm.nih.gov/pubmed/34050760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab428
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