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MTR3D: identifying regions within protein tertiary structures under purifying selection
The identification of disease-causal variants is non-trivial. By mapping population variation from over 448,000 exome and genome sequences to over 81,000 experimental structures and homology models of the human proteome, we have calculated both regional intolerance to missense variation (Missense To...
שמור ב:
| הוצא לאור ב: | Nucleic Acids Res |
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| Main Authors: | , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2021
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8265191/ https://ncbi.nlm.nih.gov/pubmed/34050760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab428 |
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