5-aza-2′-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas

BACKGROUND: Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2′-deoxycytidine (5-aza-CdR), have been suggested to treat tumors in which DNA methylation is alter...

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Veröffentlicht in:Reprod Biol Endocrinol
Hauptverfasser: Carbajo-García, María Cristina, Corachán, Ana, Segura-Benitez, Marina, Monleón, Javier, Escrig, Julia, Faus, Amparo, Pellicer, Antonio, Cervelló, Irene, Ferrero, Hortensia
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8265104/
https://ncbi.nlm.nih.gov/pubmed/34233687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12958-021-00790-5
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