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A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses

BACKGROUND: Our previous studies have shown that combining the antiviral lectin GRFT and the pan-CoV fusion inhibitory peptide EK1 results in highly potent inhibitory activity against SARS-CoV-2 infection. In this study, we aimed to design and construct a bivalent protein consisting of GRFT and EK1...

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Bibliografiske detaljer
Udgivet i:Cell Biosci
Main Authors: Cai, Yanxing, Xu, Wei, Tang, Jiayi, Cao, Najing, Lan, Qiaoshuai, Lu, Lu, Jiang, Shibo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264481/
https://ncbi.nlm.nih.gov/pubmed/34238357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13578-021-00638-w
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