Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death

The growth factor Flt3 ligand (Flt3L) is central to dendritic cell (DC) homeostasis and development, controlling survival and expansion by binding to Flt3 receptor tyrosine kinase on the surface of DCs. In the context of hematopoietic cell transplantation, Flt3L has been found to suppress graft-vers...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Molina, Megan S., Hoffman, Emely A., Stokes, Jessica, Kummet, Nicole, Smith, Kyle A., Baker, Forrest, Zúñiga, Tiffany M., Simpson, Richard J., Katsanis, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264365/
https://ncbi.nlm.nih.gov/pubmed/34249005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.699128
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