Regulatory Dendritic Cells Induced by Bendamustine Are Associated With Enhanced Flt3 Expression and Alloreactive T-Cell Death

The growth factor Flt3 ligand (Flt3L) is central to dendritic cell (DC) homeostasis and development, controlling survival and expansion by binding to Flt3 receptor tyrosine kinase on the surface of DCs. In the context of hematopoietic cell transplantation, Flt3L has been found to suppress graft-vers...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Molina, Megan S., Hoffman, Emely A., Stokes, Jessica, Kummet, Nicole, Smith, Kyle A., Baker, Forrest, Zúñiga, Tiffany M., Simpson, Richard J., Katsanis, Emmanuel
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2021
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264365/
https://ncbi.nlm.nih.gov/pubmed/34249005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.699128
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