In Rheumatoid Arthritis Patients, HLA-DRB1*04:01 and Rheumatoid Nodules Are Associated With ACPA to a Particular Fibrin Epitope

OBJECTIVES: Rheumatoid arthritis (RA) is associated with HLA-DRB1 genes encoding the shared epitope (SE), a 5-amino acid motive. RA is usually preceded by the emergence of anti-citrullinated protein/peptide antibodies (ACPAs). Citrulline is a neutral amino acid resulting from post-translational modi...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Larid, Guillaume, Pancarte, Mikael, Offer, Géraldine, Clavel, Cyril, Martin, Marielle, Pradel, Vincent, Auger, Isabelle, Lafforgue, Pierre, Roudier, Jean, Serre, Guy, Balandraud, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8264359/
https://ncbi.nlm.nih.gov/pubmed/34248985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.692041
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