Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to ACPA(+) rheumatoid arthritis and ACPA levels in Japanese population

BACKGROUND: HLA-DRB1 is the strongest susceptibility gene to rheumatoid arthritis (RA). HLA-DRB1 alleles showed significant non-additive and interactive effects on susceptibility to RA in the European population, but these effects on RA susceptibility should vary between populations due to the diffe...

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Publicado en:J Med Genet
Autores principales: Terao, Chikashi, Okada, Yukinori, Ikari, Katsunori, Kochi, Yuta, Suzuki, Akari, Ohmura, Koichiro, Matsuo, Keitaro, Taniguchi, Atsuo, Kubo, Michiaki, Raychaudhuri, Soumya, Yamamoto, Kazuhiko, Yamanaka, Hisashi, Kamatani, Yoichiro, Mimori, Tsuneyo, Matsuda, Fumihiko
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724214/
https://ncbi.nlm.nih.gov/pubmed/29025870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmedgenet-2017-104779
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