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Improved genetic prediction of complex traits from individual-level data or summary statistics

Most existing tools for constructing genetic prediction models begin with the assumption that all genetic variants contribute equally towards the phenotype. However, this represents a suboptimal model for how heritability is distributed across the genome. Therefore, we develop prediction tools that...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Qianqian, Privé, Florian, Vilhjálmsson, Bjarni, Speed, Doug
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263809/
https://ncbi.nlm.nih.gov/pubmed/34234142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24485-y
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