A preclinical report of a cobimetinib-inspired novel anticancer small-molecule scaffold of isoflavones, NSC777213, for targeting PI3K/AKT/mTOR/MEK in multiple cancers

The phosphatidylinositol 3-kinase (PI3K)/protein kinase B/mammalian target of rapamycin (mTOR) and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling pathways are critical for normal human physiology, and any alteration in their regulation leads to seve...

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Publicat a:Am J Cancer Res
Autors principals: Lawal, Bashir, Lo, Wen-Cheng, Mokgautsi, Ntlotlang, Sumitra, Maryam Rachmawati, Khedkar, Harshita, Wu, Alexander TH, Huang, Hsu-Shan
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2021
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8263676/
https://ncbi.nlm.nih.gov/pubmed/34249417
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