Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines

Signal transducer and activator of transcription 3 (STAT3) is a transcriptional regulator of a number of biological processes including cell differentiation, proliferation, survival, and angiogenesis, while cyclin-dependent kinases (CDKs) are a critical regulator of cell cycle progression. These pro...

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Publicado no:Biomedicines
Main Authors: Lawal, Bashir, Liu, Yen-Lin, Mokgautsi, Ntlotlang, Khedkar, Harshita, Sumitra, Maryam Rachmawati, Wu, Alexander T. H., Huang, Hsu-Shan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7832910/
https://ncbi.nlm.nih.gov/pubmed/33477856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9010092
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