Circadian Clock Control of Translation Initiation Factor eIF2α Activity Requires eIF2γ-Dependent Recruitment of Rhythmic PPP-1 Phosphatase in Neurospora crassa

The circadian clock controls the phosphorylation and activity of eukaryotic translation initiation factor 2α (eIF2α). In Neurospora crassa, the clock drives a daytime peak in the activity of the eIF2α kinase CPC-3, the homolog of yeast and mammalian GCN2 kinase. This leads to increased levels of pho...

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Bibliographic Details
Published in:mBio
Main Authors: Ding, Zhaolan, Lamb, Teresa M., Boukhris, Ahmad, Porter, Rachel, Bell-Pedersen, Deborah
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262944/
https://ncbi.nlm.nih.gov/pubmed/34006661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00871-21
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