Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity

The high specificity of bacteriophages is driven by their receptor-binding proteins (RBPs). Many Klebsiella bacteriophages target the capsular exopolysaccharide as the receptor and encode RBPs with depolymerase activity. The modular structure of these RBPs with an N-terminal structural module to att...

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Publicado en:mBio
Autores principales: Latka, Agnieszka, Lemire, Sebastien, Grimon, Dennis, Dams, Dorien, Maciejewska, Barbara, Lu, Timothy, Drulis-Kawa, Zuzanna, Briers, Yves
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2021
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262889/
https://ncbi.nlm.nih.gov/pubmed/33947754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00455-21
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