Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

Selective targeting of aneuploid cells is an attractive strategy for cancer treatment(1). Here, we mapped the aneuploidy landscapes of ~1,000 human cancer cell lines, and analyzed genetic and chemical perturbation screens(2–9) to reveal aneuploidy-associated cellular vulnerabilities. We identified a...

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Pubblicato in:Nature
Autori principali: Cohen-Sharir, Yael, McFarland, James M., Abdusamad, Mai, Marquis, Carolyn, Bernhard, Sara V., Kazachkova, Mariya, Tang, Helen, Ippolito, Marica R., Laue, Kathrin, Zerbib, Johanna, Malaby, Heidi L.H., Jones, Andrew, Stautmeister, Lisa-Marie, Bockaj, Irena, Wardenaar, René, Lyons, Nicholas, Nagaraja, Ankur, Bass, Adam J., Spierings, Diana C.J., Foijer, Floris, Beroukhim, Rameen, Santaguida, Stefano, Golub, Todd R., Stumpff, Jason, Storchova, Zuzana, Ben-David, Uri
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262644/
https://ncbi.nlm.nih.gov/pubmed/33505028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-03114-6
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