Deficiency of histone lysine methyltransferase SETDB2 in hematopoietic cells promotes vascular inflammation and accelerates atherosclerosis

Epigenetic modifications of the genome, including DNA methylation, histone methylation/acetylation, and noncoding RNAs, have been reported to play a fundamental role in regulating immune response during the progression of atherosclerosis. SETDB2 is a member of the KMT1 family of lysine methyltransfe...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:JCI Insight
Main Authors: Zhang, Xinbo, Sun, Jonathan, Canfrán-Duque, Alberto, Aryal, Binod, Tellides, George, Chang, Ying Ju, Suárez, Yajaira, Osborne, Timothy F., Fernández-Hernando, Carlos
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2021
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262461/
https://ncbi.nlm.nih.gov/pubmed/34003795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.147984
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