Enhanced Catecholamine Flux and Impaired Carbonyl Metabolism Disrupt Cardiac Mitochondrial Oxidative Phosphorylation in Diabetes Patients

Aims: Catecholamine metabolism via monoamine oxidase (MAO) contributes to cardiac injury in models of ischemia and diabetes, but the pathogenic mechanisms involved are unclear. MAO deaminates norepinephrine (NE) and dopamine to produce H(2)O(2) and highly reactive “catecholaldehydes,” which may be t...

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Dettagli Bibliografici
Pubblicato in:Antioxid Redox Signal
Autori principali: Nelson, Margaret-Ann M., Efird, Jimmy T., Kew, Kimberly A., Katunga, Lalage A., Monroe, T. Blake, Doorn, Jonathan A., Beatty, Cherese N., Shi, Qian, Akhter, Shahab A., Alwair, Hazaim, Robidoux, Jacques, Anderson, Ethan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc., publishers 2021
Soggetti:
Forum Original Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262387/
https://ncbi.nlm.nih.gov/pubmed/33066717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2020.8122
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