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Implications of a granulocyte-high glioblastoma microenvironment in immune suppression and therapy resistance()

The failure of anti-VEGF/R and immune checkpoint therapies to improve overall survival in Phase III clinical trials in glioblastoma (GBM) is considered to be due in part to the prevalent immunosuppression in the GBM tumor microenvironment. Immune suppression is mediated in part by resident microglia...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Krishnan, Shanmugarajan, Amoozgar, Zohreh, Fukumura, Dai, Jain, Rakesh K
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262382/
https://ncbi.nlm.nih.gov/pubmed/33534142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5637
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