Unconjugated p-cresol activates macrophage macropinocytosis leading to increased LDL uptake

Patients with chronic kidney disease (CKD) and end-stage renal disease suffer from increased cardiovascular events and cardiac mortality. Prior studies have demonstrated that a portion of this enhanced risk can be attributed to the accumulation of microbiota-derived toxic metabolites, with most stud...

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Опубликовано в: :JCI Insight
Главные авторы: Chaves, Lee D., Abyad, Sham, Honan, Amanda M., Bryniarski, Mark A., McSkimming, Daniel I., Stahura, Corrine M., Wells, Steven C., Ruszaj, Donna M., Morris, Marilyn E., Quigg, Richard J., Yacoub, Rabi
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2021
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8262368/
https://ncbi.nlm.nih.gov/pubmed/33914709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144410
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