Vaginal Squamous Cell Carcinoma Develops in Mice with Conditional Arid1a Loss and Gain of Oncogenic Kras Driven by Progesterone Receptor Cre

Oncogenic KRAS mutations are a common finding in endometrial cancers. Recent sequencing studies indicate that loss-of-function mutations in the ARID1A gene are enriched in gynecologic malignant tumors. However, neither of these genetic insults alone are sufficient to develop gynecologic cancer. To d...

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Bibliografische gegevens
Gepubliceerd in:Am J Pathol
Hoofdauteurs: Wang, Xiyin, Praça, Mariana S.L., Wendel, Jillian R.H., Emerson, Robert E., DeMayo, Francesco J., Lydon, John P., Hawkins, Shannon M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Investigative Pathology 2021
Onderwerpen:
Regular Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8261476/
https://ncbi.nlm.nih.gov/pubmed/33882289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.03.013
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