EZH2-induced lysine K362 methylation enhances TMPRSS2-ERG oncogenic activity in prostate cancer

The TMPRSS2-ERG gene fusion is the most frequent alteration observed in human prostate cancer. However, its role in disease progression is still unclear. In this study, we uncover an important mechanism promoting ERG oncogenic activity. We show that ERG is methylated by Enhancer of zest homolog 2 (E...

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Vydáno v:Nat Commun
Hlavní autoři: Zoma, Marita, Curti, Laura, Shinde, Dheeraj, Albino, Domenico, Mitra, Abhishek, Sgrignani, Jacopo, Mapelli, Sarah N., Sandrini, Giada, Civenni, Gianluca, Merulla, Jessica, Chiorino, Giovanna, Kunderfranco, Paolo, Cacciatore, Alessia, Kokanovic, Aleksandra, Rinaldi, Andrea, Cavalli, Andrea, Catapano, Carlo V., Carbone, Giuseppina M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260656/
https://ncbi.nlm.nih.gov/pubmed/34230470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24380-6
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