Inhibition of Elevated Ras-MAPK Signaling Normalizes Enhanced Motor Learning and Excessive Clustered Dendritic Spine Stabilization in the MECP2-Duplication Syndrome Mouse Model of Autism

The inflexible repetitive behaviors and “insistence on sameness” seen in autism imply a defect in neural processes controlling the balance between stability and plasticity of synaptic connections in the brain. It has been proposed that abnormalities in the Ras-ERK/MAPK pathway, a key plasticity-rela...

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Udgivet i:eNeuro
Main Authors: Ash, Ryan Thomas, Buffington, Shelly Alexandra, Park, Jiyoung, Suter, Bernhard, Costa-Mattioli, Mauro, Zoghbi, Huda Yaya, Smirnakis, Stelios Manolis
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2021
Fag:
Research Article: New Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260274/
https://ncbi.nlm.nih.gov/pubmed/34021030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0056-21.2021
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