Translation stress and collided ribosomes are co-activators of cGAS

The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system. Here, we report the unexpected discovery that cGAS also senses dysfunctional protein production. Purified ribosome...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Wan, Li, Juszkiewicz, Szymon, Blears, Daniel, Bajpe, Prashanth Kumar, Han, Zhong, Faull, Peter, Mitter, Richard, Stewart, Aengus, Snijders, Ambrosius P., Hegde, Ramanujan S., Svejstrup, Jesper Q.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260207/
https://ncbi.nlm.nih.gov/pubmed/34111399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.05.018
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