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Translation stress and collided ribosomes are co-activators of cGAS
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system. Here, we report the unexpected discovery that cGAS also senses dysfunctional protein production. Purified ribosome...
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| Publicat a: | Mol Cell |
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| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cell Press
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8260207/ https://ncbi.nlm.nih.gov/pubmed/34111399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.05.018 |
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