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Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin

Polymers that stabilize biomolecules are important as excipients in protein formulation. Herein, we describe a class of degradable polymers that have tunable degradation rates depending on the polymer backbone and are able to stabilize proteins to aggregation. Specifically, zwitterion- and trehalose...

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Detalhes bibliográficos
Publicado no:Biomacromolecules
Main Authors: Pelegri-O’Day, Emma M., Bhattacharya, Arvind, Theopold, Nik, Ko, Jeong Hoon, Maynard, Heather D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259896/
https://ncbi.nlm.nih.gov/pubmed/32369347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biomac.0c00133
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