Anti-CD20 mAb-Induced B Cell Apoptosis Generates T Cell Regulation of Experimental Myeloperoxidase ANCA-Associated Vasculitis

BACKGROUND: Myeloperoxidase ANCA-associated vasculitis is a major cause of ESKD. Efficacy of anti-CD20 mAb treatment was tested in a mouse model of the disease. METHODS: MPO immunization induced anti-MPO autoimmunity, and a subnephritogenic dose of sheep anti-mouse GBM globulin triggered GN. RESULTS...

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Udgivet i:J Am Soc Nephrol
Main Authors: Gan, Poh-Yi, Dick, Jonathan, O’Sullivan, Kim M., Oudin, Virginie, Cao Le, Anne, Koo Yuk Cheong, Daniel, Shim, Raymond, Alikhan, Maliha, Kitching, A. Richard, Ooi, Joshua D., Holdsworth, Stephen R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2021
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259682/
https://ncbi.nlm.nih.gov/pubmed/33789951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020060834
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