The C3aR promotes macrophage infiltration and regulates ANCA production but does not affect glomerular injury in experimental anti-myeloperoxidase glomerulonephritis

The anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitides are autoimmune diseases associated with significant morbidity and mortality. They often affect the kidney causing rapidly progressive glomerulonephritis. While signalling by complement anaphylatoxin C5a though the C5a receptor i...

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Udgivet i:PLoS One
Main Authors: Dick, Jonathan, Gan, Poh-Yi, Kitching, A. Richard, Holdsworth, Stephen R.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760037/
https://ncbi.nlm.nih.gov/pubmed/29315316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0190655
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