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DNA mismatch repair-deficient endometrial carcinosarcomas portend distinct clinical, morphological and molecular features compared to traditional carcinosarcomas
BACKGROUND: Uterine carcinosarcomas (UCSs) are aggressive neoplasms composed of high-grade malignant epithelial and mesenchymal elements with most (~90%) showing TP53 abnormalities. A subset, however, shows mismatch repair deficiency (MMR-D). We sought to describe their clinical, morphologic and mol...
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| Udgivet i: | Am J Surg Pathol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8259346/ https://ncbi.nlm.nih.gov/pubmed/32804882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000001561 |
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