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DNA mismatch repair-deficient endometrial carcinosarcomas portend distinct clinical, morphological and molecular features compared to traditional carcinosarcomas

BACKGROUND: Uterine carcinosarcomas (UCSs) are aggressive neoplasms composed of high-grade malignant epithelial and mesenchymal elements with most (~90%) showing TP53 abnormalities. A subset, however, shows mismatch repair deficiency (MMR-D). We sought to describe their clinical, morphologic and mol...

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Detalhes bibliográficos
Publicado no:Am J Surg Pathol
Main Authors: Segura, SE, Pedra Nobre, S, Hussein, YR, Abu-Rustum, NR, Weigelt, B, Soslow, RA, DeLair, DF
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259346/
https://ncbi.nlm.nih.gov/pubmed/32804882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/PAS.0000000000001561
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