Cobalt-Catalyzed C–H Activation/Annulation of Benzamides with Fluorine-Containing Alkynes: A Route to 3- and 4-Fluoroalkylated Isoquinolinones

The C–H activation/annulation reaction of various benzamides with fluoroalkylated alkynes in the presence of a Co(acac)(2)·2H(2)O catalyst proceeded very smoothly to give the corresponding 3- and 4-fluoroalkylated isoquinolinones in excellent yields with approximately 70% regioselectivities. These r...

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Bibliografske podrobnosti
izdano v:J Org Chem
Main Authors: Kumon, Tatsuya, Wu, Jianyan, Shimada, Miroku, Yamada, Shigeyuki, Agou, Tomohiro, Fukumoto, Hiroki, Kubota, Toshio, Hammond, Gerald B., Konno, Tsutomu
Format: Artigo
Jezik:Inglês
Izdano: 2021
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8259111/
https://ncbi.nlm.nih.gov/pubmed/33725448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.1c00080
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