Coordinated changes in gene expression kinetics underlie both mouse and human erythroid maturation

BACKGROUND: Single-cell technologies are transforming biomedical research, including the recent demonstration that unspliced pre-mRNA present in single-cell RNA-Seq permits prediction of future expression states. Here we apply this RNA velocity concept to an extended timecourse dataset covering mous...

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Veröffentlicht in:Genome Biol
Hauptverfasser: Barile, Melania, Imaz-Rosshandler, Ivan, Inzani, Isabella, Ghazanfar, Shila, Nichols, Jennifer, Marioni, John C., Guibentif, Carolina, Göttgens, Berthold
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258993/
https://ncbi.nlm.nih.gov/pubmed/34225769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02414-y
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