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A pilot study of the pan-class I PI3K inhibitor buparlisib in combination with cetuximab in patients with recurrent or metastatic head and neck cancer

BACKGROUND: This study assessed the maximum tolerated dose (MTD) of the PI3K inhibitor buparlisib given concurrently with cetuximab in recurrent and metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). METHODS: Twelve patients with R/M HNSCC were enrolled. Patients were given oral buparli...

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Detalhes bibliográficos
Publicado no:Head Neck
Main Authors: Brisson, Ryan J., Kochanny, Sara, Arshad, Saba, Dekker, Allison, DeSouza, Jonas A., Saloura, Vassiliki, Vokes, Everett E., Seiwert, Tanguy Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258680/
https://ncbi.nlm.nih.gov/pubmed/31486207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hed.25910
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