Ex Vivo Antibody-Dependent Cellular Cytotoxicity Inducibility Predicts Efdicacy of Cetuximab

We conducted in vitro studies and a clinical trial for patients with squamous cell carcinoma of the head and neck (SCCHN) to study the relationship between FcγRIIIa polymorphisms and antibody-dependent cellular cytotoxicity (ADCC). In vitro, FcγRIIIa genotype was correlated with ADCC and innate cyto...

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Pubblicato in:Cancer Immunol Res
Autori principali: Taylor, Rodney J., Saloura, Vassiliki, Jain, Ajay, Goloubeva, Olga, Wong, Stuart, Kronsberg, Shari, Nagilla, Madhavi, Silpino, Lorna, de Souza, Jonas, Seiwert, Tanguy, Vokes, Everett, Villaflor, Victoria, Cohen, Ezra E.W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4681575/
https://ncbi.nlm.nih.gov/pubmed/25769300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0188
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