Renal Function Decline With Small Interfering RNA Silencing Aminolevulinic Acid Synthase 1 (ALAS1)

INTRODUCTION: Givosiran is an RNA interference therapeutic designed to block the synthesis of the aminolevulinic acid (ALA) synthase 1 (ALAS1) enzyme in patients with acute intermittent porphyria (AIP). Givosiran may have adverse effects on the kidney. METHODS: We performed a descriptive case series...

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Dettagli Bibliografici
Pubblicato in:Kidney Int Rep
Autori principali: Lazareth, Hélène, Poli, Antoine, Bignon, Yohan, Mirmiran, Arienne, Rabant, Marion, Cohen, Raphaël, Schmitt, Caroline, Puy, Hervé, Karras, Alexandre, Gouya, Laurent, Pallet, Nicolas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
Soggetti:
Clinical Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8258458/
https://ncbi.nlm.nih.gov/pubmed/34307985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ekir.2021.04.004
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