Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

Aminolevulinic acid (ALA) is an endogenous metabolite normally formed in the mitochondria from succinyl-CoA and glycine. Conjugation of eight ALA molecules yields protoporphyrin IX (PpIX) and finally leads to formation of heme. Conversion of PpIX to its downstream substrates requires the activity of...

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Bibliographic Details
Published in:Molecules
Main Authors: Wachowska, Małgorzata, Muchowicz, Angelika, Firczuk, Małgorzata, Gabrysiak, Magdalena, Winiarska, Magdalena, Wańczyk, Małgorzata, Bojarczuk, Kamil, Golab, Jakub
Format: Artigo
Language:Inglês
Published: MDPI 2011
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263343/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules16054140
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