Mutational Analysis of the GXXXG/A Motifs in the Human Na(+)/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function

Homodimerization is essential for plasma membrane sorting of the liver bile acid transporter NTCP and its function as Hepatitis B/D Virus (HBV/HDV) receptor. However, the protein domains involved in NTCP dimerization are unknown. NTCP bears two potential GXXXG/A dimerization motifs in its transmembr...

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Bibliographische Detailangaben
Veröffentlicht in:Front Mol Biosci
Hauptverfasser: Palatini, Massimo, Müller, Simon Franz, Lowjaga, Kira Alessandra Alicia Theresa, Noppes, Saskia, Alber, Jörg, Lehmann, Felix, Goldmann, Nora, Glebe, Dieter, Geyer, Joachim
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Molecular Biosciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257933/
https://ncbi.nlm.nih.gov/pubmed/34239896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2021.699443
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