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Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

BACKGROUND: Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the type and frequency of mutations arising in the mucosa of the small intestine of m...

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Detalhes bibliográficos
Publicado no:Genes Environ
Main Authors: Aoki, Yasunobu, Ohno, Mizuki, Matsumoto, Michiyo, Matsumoto, Michi, Masumura, Kenichi, Nohmi, Takehiko, Tsuzuki, Teruhisa
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256579/
https://ncbi.nlm.nih.gov/pubmed/34225823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-021-00196-0
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