Phage-encoded ten-eleven translocation dioxygenase (TET) is active in C5-cytosine hypermodification in DNA

TET/JBP (ten-eleven translocation/base J binding protein) enzymes are iron(II)- and 2-oxo-glutarate–dependent dioxygenases that are found in all kingdoms of life and oxidize 5-methylpyrimidines on the polynucleotide level. Despite their prevalence, few examples have been biochemically characterized....

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Burke, Evan J., Rodda, Samuel S., Lund, Sean R., Sun, Zhiyi, Zeroka, Malcolm R., O’Toole, Katherine H., Parker, Mackenzie J., Doshi, Dharit S., Guan, Chudi, Lee, Yan-Jiun, Dai, Nan, Hough, David M., Shnider, Daria A., Corrêa, Ivan R., Weigele, Peter R., Saleh, Lana
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256090/
https://ncbi.nlm.nih.gov/pubmed/34155108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026742118
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