Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene

Multiple independent sequence variants of the hTERT locus have been associated with telomere length and cancer risks in genome-wide association studies. Here, we identified an intronic variable number tandem repeat, VNTR2-1, as an enhancer-like element, which activated hTERT transcription in a cell...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xu, Tao, Cheng, De, Zhao, Yuanjun, Zhang, Jinglong, Zhu, Xiaolu, Zhang, Fan, Chen, Gang, Wang, Yang, Yan, Xiufeng, Robertson, Gavin P., Gaddameedhi, Shobhan, Lazarus, Philip, Wang, Shuwen, Zhu, Jiyue
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8256013/
https://ncbi.nlm.nih.gov/pubmed/34155099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019043118
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