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FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents
Heterozygous loss-of-function mutations in the transcription factor FOXP1 are strongly associated with autism. Dopamine receptor 2 expressing (D2) striatal projection neurons (SPNs) in heterozygous Foxp1 (Foxp1(+/−)) mice have higher intrinsic excitability. To understand the mechanisms underlying th...
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| Pubblicato in: | Mol Psychiatry |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8255328/ https://ncbi.nlm.nih.gov/pubmed/33402705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-00995-x |
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