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Exploring lipid-dependent conformations of membrane-bound α-synuclein with the VDAC nanopore

Regulation of VDAC by α-Synuclein (αSyn) is a rich and instructive example of protein-protein interactions catalyzed by a lipid membrane surface. αSyn, a peripheral membrane protein involved in Parkinson’s disease pathology, is known to bind to membranes in a transient manner. αSyn’s negatively char...

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Vydáno v:Biochim Biophys Acta Biomembr
Hlavní autoři: Hoogerheide, David P., Rostovtseva, Tatiana K., Bezrukov, Sergey M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8255272/
https://ncbi.nlm.nih.gov/pubmed/33971161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2021.183643
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