Alpha-Synuclein Lipid-Dependent Membrane Binding and Translocation through the α-Hemolysin Channel

Gauging the interactions of a natively unfolded Parkinson disease-related protein, alpha-synuclein (α-syn) with membranes and its pathways between and within cells is important for understanding its pathogenesis. Here, to address these questions, we use a robust β-barrel channel, α-hemolysin, recons...

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Hlavní autoři: Gurnev, Philip A., Yap, Thai Leong, Pfefferkorn, Candace M., Rostovtseva, Tatiana K., Berezhkovskii, Alexander M., Lee, Jennifer C., Parsegian, V. Adrian, Bezrukov, Sergey M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2014
Témata:
Channels and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944825/
https://ncbi.nlm.nih.gov/pubmed/24507596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.12.028
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