Isolation and characterization of fetal nucleated red blood cells from maternal blood as a target for single cell sequencing‐based non‐invasive genetic testing

PURPOSE: Although non‐invasive prenatal testing (NIPT) based on cell‐free DNA (cfDNA) in maternal plasma has been prevailing worldwide, low levels of fetal DNA fraction may lead to false‐negative results. Since fetal cells in maternal blood provide a pure source of fetal genomic DNA, we aimed to est...

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Detalles Bibliográficos
Publicado en:Reprod Med Biol
Main Authors: Ito, Noriko, Tsukamoto, Kazuhiro, Taniguchi, Kosuke, Takahashi, Ken, Okamoto, Aikou, Aoki, Hiroaki, Otera‐Takahashi, Yuka, Kitagawa, Michihiro, Ogata‐Kawata, Hiroko, Morita, Hideaki, Hata, Kenichiro, Nakabayashi, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
Assuntos:
Original Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8254165/
https://ncbi.nlm.nih.gov/pubmed/34262404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rmb2.12392
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