RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets

OBJECTIVE: To identify key determinants of the interactive pathophysiologic processes in subchondral bone and cartilage in osteoarthritis (OA). METHODS: We performed RNA sequencing on macroscopically preserved and lesional OA subchondral bone from patients in the Research Arthritis and Articular Car...

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Bibliografiske detaljer
Udgivet i:Arthritis Rheumatol
Main Authors: Tuerlings, Margo, van Hoolwerff, Marcella, Houtman, Evelyn, Suchiman, Eka H. E. D., Lakenberg, Nico, Mei, Hailiang, van der Linden, Enrike H. M. J., Nelissen, Rob R. G. H. H., Ramos, Yolande Y. F. M., Coutinho de Almeida, Rodrigo, Meulenbelt, Ingrid
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Osteoarthritis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252798/
https://ncbi.nlm.nih.gov/pubmed/33258547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41600
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