RNA Sequencing Reveals Interacting Key Determinants of Osteoarthritis Acting in Subchondral Bone and Articular Cartilage: Identification of IL11 and CHADL as Attractive Treatment Targets

OBJECTIVE: To identify key determinants of the interactive pathophysiologic processes in subchondral bone and cartilage in osteoarthritis (OA). METHODS: We performed RNA sequencing on macroscopically preserved and lesional OA subchondral bone from patients in the Research Arthritis and Articular Car...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arthritis Rheumatol
Prif Awduron: Tuerlings, Margo, van Hoolwerff, Marcella, Houtman, Evelyn, Suchiman, Eka H. E. D., Lakenberg, Nico, Mei, Hailiang, van der Linden, Enrike H. M. J., Nelissen, Rob R. G. H. H., Ramos, Yolande Y. F. M., Coutinho de Almeida, Rodrigo, Meulenbelt, Ingrid
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2021
Pynciau:
Osteoarthritis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252798/
https://ncbi.nlm.nih.gov/pubmed/33258547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41600
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