Apical CLC‐2 in retinal pigment epithelium is crucial for survival of the outer retina

Knockout of the chloride channel protein 2 (CLC‐2; CLCN2) results in fast progressing blindness in mice. Retinal Pigment Epithelium (RPE) and photoreceptors undergo, in parallel, rapid, and profound morphological changes and degeneration. Immunohistochemistry and electron microscopy of the outer ret...

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Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Hanke‐Gogokhia, Christin, Lehmann, Guillermo L., Benedicto, Ignacio, de la Fuente‐Ortega, Erwin, Arshavsky, Vadim Y., Schreiner, Ryan, Rodriguez‐Boulan, Enrique
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252757/
https://ncbi.nlm.nih.gov/pubmed/34085737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.202100349R
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