Synthesis and in Vitro Evaluation of Novel 5‐Nitroindole Derivatives as c‐Myc G‐Quadruplex Binders with Anticancer Activity

Lead‐optimization strategies for compounds targeting c‐Myc G‐quadruplex (G4) DNA are being pursued to develop anticancer drugs. Here, we investigate the structure‐activity‐ relationship (SAR) of a newly synthesized series of molecules based on the pyrrolidine‐substituted 5‐nitro indole scaffold to t...

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Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Nimbarte, Vijaykumar D., Wirmer‐Bartoschek, Julia, Gande, Santosh L., Alshamleh, Islam, Seibert, Marcel, Nasiri, Hamid Reza, Schnütgen, Frank, Serve, Hubert, Schwalbe, Harald
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252724/
https://ncbi.nlm.nih.gov/pubmed/33508167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000835
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