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Direct Catalytic N‐Alkylation of α‐Amino Acid Esters and Amides Using Alcohols with High Retention of Stereochemistry

The direct functionalization of naturally abundant chiral scaffolds such as α‐amino acid esters or amides with widely abundant alcohols, without any racemization, is a demanding transformation that is of central importance for the synthesis of bio‐active compounds. Herein a robust and general method...

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Publicat a:ChemSusChem
Autors principals: Yan, Tao, Feringa, Ben L., Barta, Katalin
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252633/
https://ncbi.nlm.nih.gov/pubmed/33961350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cssc.202100373
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