Cerebral amyloid‐β load is associated with neurodegeneration and gliosis: Mediation by p‐tau and interactions with risk factors early in the Alzheimer's continuum

INTRODUCTION: The association between cerebral amyloid‐β accumulation and downstream CSF biomarkers is not fully understood, particularly in asymptomatic stages. METHODS: In 318 cognitively unimpaired participants, we assessed the association between amyloid‐β PET (Centiloid), and cerebrospinal flui...

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Detalhes bibliográficos
Publicado no:Alzheimers Dement
Main Authors: Salvadó, Gemma, Milà‐Alomà, Marta, Shekari, Mahnaz, Minguillon, Carolina, Fauria, Karine, Niñerola‐Baizán, Aida, Perissinotti, Andrés, Kollmorgen, Gwendlyn, Buckley, Christopher, Farrar, Gill, Zetterberg, Henrik, Blennow, Kaj, Suárez‐Calvet, Marc, Molinuevo, José Luis, Gispert, Juan Domingo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252618/
https://ncbi.nlm.nih.gov/pubmed/33663013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12245
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